How to Make Water Soluble CBD CBG CBN D9

Where Do Your Water Soluble Cannabinoids Come From?
The Confidence of a Clear Chain of Custody

Water Soluble cannabinoids—especially CBD, CBG and CBN—are rapidly becoming essential ingredients for functional beverages, nutraceuticals and wellness products, but not all water soluble formulations are created equal. The quality, safety, bioavailability, regulatory compliance and performance of water-soluble cannabinoids depend entirely on how they are manufactured, the purity of the input materials and the transparency of the supply chain. For brands seeking consistent dosing, increased bioavailability and stability, understanding how water-soluble cannabinoids are made and the importance of vertical integration, advanced nanoemulsion technology and full chain-of-custody transparency is critical to product success, consumer trust and scalable growth.

Key Takeaways: Understanding Nanoemulsion and It’s Role in Bioavailability, Stability and Water Solubility

What are water-soluble cannabinoids?
Hemp-derived Water-soluble cannabinoids are produced using manufacturing techniques such as nanoemulsification, which allow oil-based cannabinoids to disperse evenly in water, unlike traditional cannabinoid oils, which tend to separate in liquid form. The results are consistent dosing, compatibility with water-based formulations and improved stability and bioavailability.
How are water-soluble cannabinoids made?
Water-soluble cannabinoids are produced by purifying hemp extract into an isolate, homogenizing it to ensure consistency and then using nanoemulsion technology. This elaborate method produces microscopic-size cannabinoid oil droplets, keeping them evenly distributed in water-based formulations and preventing separation or settling.
Why is nanoemulsion used for cannabinoids?
Nanoemulsion technology is used because it creates water-compatible nano-sized droplets that increase surface area, potentially enhancing absorption, stability and even dispersion of cannabinoids in liquid formulations.
What is THC-free isolate and why is it the input materials for nanoemulsion?
THC-free isolate is a highly purified cannabinoid raw ingredient containing a single cannabinoid compound with non-detectable THC levels. It is processed first through distillation and then crystallization to achieve near-pure potency, making it easier to formulate precise doses and meet regulatory requirements. It is the ideal input material due to its high potency and purity for targeted health and wellness benefits.
Why does vertical integration matter in cannabinoid manufacturing?
Vertical integration improves quality control because one manufacturer oversees every stage of production—from raw hemp to finished ingredient. This reduces the risk of contamination, ensures batch consistency, provides traceability and minimizes supply disruptions associated with third-party sourcing.
Are water-soluble cannabinoids better for beverages?
Yes. Water-soluble cannabinoids are preferred for beverages because they mix evenly, resist separation, maintain potency and have minimal impact on taste. These properties are important to help ensure shelf-stable functional drinks and ready-to-drink formulations.
How does particle size affect cannabinoid performance?
A smaller particle size can improve stability, uniformity and absorption. Nano-scale droplets offer a larger surface area, allowing more of the cannabinoid to penetrate mucus membranes directly, such as the mouth or stomach lining. In addition, nanoemulsified CBD, CBG or CBN disperses more evenly in water-based formulations, preventing settling and providing more predictable dosing.
What certifications should a cannabinoid manufacturer have?
A reputable manufacturer typically operates under ISO certification, cGMP compliance, FDA food facility registration and provides ISO-accredited third-party lab Certificates of Analysis (COAs). These standards indicate highly controlled manufacturing, validated testing and compliance with recognized safety regulations.
Are water-soluble cannabinoids more bioavailable?
They can be. Nanoemulsions that are properly manufactured may enhance absorption because smaller droplets are more readily absorbed. Actual bioavailability depends on formulation factors such as particle size, emulsifiers and overall delivery system design.
What industries use water-soluble cannabinoids?
Water-soluble cannabinoids are widely used in functional beverages, nutraceuticals, dietary supplements, functional shots, powdered drink mixes and wellness formulations that require stable, scalable, and precisely dosed ingredients compatible with water-based products.
What is a Certificate of Analysis (COA)?
A Certificate of Analysis is an independent  third-party laboratory report verifying an ingredient’s potency, purity and safety. It validates cannabinoid content and screens for contaminants, including heavy metals, pesticides, microbes and residual solvents, to ensure regulatory compliance and product quality.

Table of Contents

THE HOW AND WHY OF WATER SOLUBLE

THE HOWHow Is Water-Soluble CBD, CBG And CBN Made?

The quality, safety and compliance of water-soluble CBD, CBG and CBN can vary considerably depending on the raw material input, the manufacturing process and the standards upheld by the manufacturer. Understandably, your priority is finding the best, safest and most reliable water-soluble cannabinoids. This means partnering with a hemp processor that upholds the highest manufacturing processes and standards, prioritizes quality and compliance, while exceeding current industry standards. Your brand’s trust and credibility depend on it.

RED MESA’S WATER SOLUBLE PROCESS – STARTS AND ENDS WITH QUALITY

Manufacturing High-Quality THC-free, Input Material

Incoming hemp material undergoes a 6-point inspection to ensure it meets our exact specifications before advancing to the homogenization and solvent recovery stage.  Once homogenized, our in-house HPLC tests verify that the material is acceptable, allowing it to proceed to our highly specialized two-stage distillation system. The resulting ultra-purified oil is then transferred to our closed-loop crystallization system. Upon completion, the THC-free, nearly 100% pure isolate is once again homogenized using an industrial-scale dedicated homogenization system to ensure consistency and quality before nanoemulsion.

Manufacturing Premium THC-Free Water Soluble Cannabinoids

Designed for scalability, our process supports the rising demand for functional beverages. Utilizing a sophisticated closed-loop system, we reduce the risk of environmental contamination commonly associated with open systems, ensuring the highest quality and safety in the production of water-soluble cannabinoids. The technology, combined with our proprietary process, transforms isolate molecules into fully homogenized, nano-encapsulated, emulsion droplets with little to no flavor in solutions. Our manufacturing process maximizes bioavailability and stability, encouraging product development and market growth.

THE WHY 

1. Vertical Integration – Consistency and Trust

Why It Matters:
Vertical integration helps eliminate batch inconsistencies, supply chain disruptions, and risks such as contamination, particle-size variations and non-compliance that are often associated with third-party sourcing of raw materials.

The Red Mesa Advantage:

  • End-to-End Control: Comprehensive oversight of the production process, from Isolate input material to the finished water-soluble cannabinoid raw ingredients, promotes consistent potency and quality.
  • Reliable Supply: Minimizes risks and variability associated with third-party sourcing, ensuring a premium-quality and dependable flow of ingredients.
  • Batch-to-Batch Uniformity: In-house production ensures homogenous cannabinoid profiles and precise particle sizes.
  • Trusted Expertise: A globally recognized, trusted producer of Isolates as input materials ensures consistent quality, purity and predictable performance.
  • Built-In Trust: Fully transparent documentation for every batch, traceable back to raw materials, operators, equipment used and even packaging components.

2. Backed by Science – Proven Nanoemulsion Technology Intended for the Food and Beverage Industry.

Why it Matters: 
Nanoemulsion technology is crucial for developing premium, effective and scalable cannabinoid-infused beverages that meet both consumer expectations and industry demands.

The Red Mesa Advantage:

  • Enhanced Formulations: Our technology and methodology deliver precise dosing, exceptional efficacy and seamless integration, ensuring a uniform, homogeneous distribution of cannabinoids throughout the beverage with minimal impact on flavor and aroma.
  • Scalability: The industrial nanoemulsion process enables large-scale production while maintaining consistent quality, making it an ideal solution for industrial applications.
  • Clarity and Stability: Nanoemulsion beverages are clear and stable with reduced cloudiness and sediment, enhancing the product’s visual appeal and shelf life.
  • Market Differentiation: High-quality, fast-acting and visually appealing beverages stand out in the competitive functional beverage market.

3. Future-Proofing Regulatory Compliance & Extending Beyond Industry Standards

Why it Matters:
The cannabinoid industry continues to evolve with uncertainty regarding federal and state regulations.

The Red Mesa Advantage:

  • Proactive Compliance: Red Mesa constantly monitors and adapts to regulatory changes to ensure ongoing compliance.
  • Certified Facility: ISO 9001:2015 end-to-end certified for strict quality and safety standards.
  • cGMP Compliant: Guarantees safety, quality and consistency while meeting regulatory requirements.
  • FDA Registered Food Facility: Fully adheres to FDA cGMP standards for dietary supplements (21 CFR Part 111) and food/beverage (21 CFR Part 117).
  • Inclusive Certifications: Kosher, Halal and Vegan certified to support global market reach and ethical practices.
  • Quality Assurance: Real-time oversight integrated into every production step.
  • Third-Party Testing: ISO 17025 accredited lab provides full-panel COAs for safety, compliance and excellence.

4. Cost-Effective

Why it Matters:
Manufacturers must strike a balance between quality and cost efficiency, especially in competitive markets.

Red Mesa’s Advantage:

  • Cost Savings: Owning the Isolate input reduces production costs, enabling competitive pricing.
  • Enhanced Efficiency: Superior bioavailability reduces the amount of cannabinoid required per serving, thereby lowering material costs in end-product formulations.
  • Flexible Ordering: Scalable options from 25g to hundreds of kilograms, tailored to your needs.

5. High-Quality, Customizable Ingredients

Why it Matters:
Beverage manufacturers require innovative ingredients to achieve product goals, target consumers’ needs and differentiate themselves in a competitive market.

The Red Mesa Advantage:

    • Input Flexibility: As the manufacturer of the Isolate inputs, Red Mesa can provide tailored CBD, CBG, CBN and Delta-9 blends to meet specific formulation needs.

6. Your Trusted Supply Chain Partner

Why it Matters: 
A trusted source in the supply chain is crucial for ensuring consistent quality, reliability and compliance while minimizing risks such as supply disruptions, contamination, or regulatory issues – all essential for building consumer trust and maintaining a competitive edge.

The Red Mesa Advantage:

  • Red Mesa offers industry expertise, vertical integration, customizable cannabinoid blends, proven regulatory compliance and scalable, high-quality production—all ensuring consistent, reliable and innovative water-soluble raw ingredients to meet market demands and consumer expectations.
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