THC-Free CBN Isolate with a guaranteed potency of 95% or greater CBN (Cannabinol) is processed and refined by abiding by stringent quality standards. For added confidence, ISO 17025 accredited third-party full-panel COAs confirm CBN Isolate quality, purity and potency while verifying federally compliant removal of pesticides, heavy metals and other impurities. 


Our sulferless CBN Isolate or Cannabinol Isolate as it is also known, is derived from US-grown hemp and considered the purest and most potent form of CBN. Our manufacturing process effectively removes all other cannabinoids, flavonoids, waxes, chlorophyll and terpenes, producing a nearly odorless and tasteless CBN Isolate powder. The resulting fine, white, highly purified CBN powder provides accurate dosing and facilitates ease in blending into other ingredients.

CBN Isolate Applications:

  • Topical – Creams, Lotions, Balms, Salves etc.
  • Skincare – Serums, Creams, Masks etc.
  • Cosmetics
  • Tinctures and Oils
  • Capsules and Soft gels
  • Edibles – Gummies, Chocolates and Other Confections


Need a larger quantity? Please contact us for custom wholesale quotes to buy larger bulk quantities or request current batch CoAs. You can also reach us via phone or email: 435.677.6363

CBN Isolate is the purest form of CBN with 95% pure CBN and is THC-Free. The fine white powder is easily mixed into formulations that require high potency CBN to capitalize upon the benefits of CBN.
Buy THC-Free bulk CBN crystalline powder with ≥ 95% pure CBN for CBN products requiring high potency CBN with zero THC at wholesale.
Bulk CBN Isolate is highly purified with zero THC and available at wholesale with minimum quantities starting at 25g up to larges scale manufacturing quantities in the thousands of kilograms. CBN Isolate is a white crystalline powder that is refined to the highest quality for CBN products such as tinctures, gummies, topicals, gel caps, soft gels and other application seeking the highest potency CBN
Buy CBN Isolate High Purity CBN with Zero THC manufactured by Red Mesa Science and Refining
CBN Isolate 97 percent pure bulk CBN at wholesale prices online
CBN Isolate is the purest for of CBN and is THC-Free - available in bulk packaging copy
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Red Mesa Science & Refining's Quality Badge represents the use of an ISO 17025 accredited third party lab COAs to validate Red Mesa's CBD Isolate, CBD Distillate, CBG Isolate and CBG Distillate high quality and trustworthiness.

Delivering What We Promise

Full panel ISO 17025 Accredited Third-Party Lab COAs for added confidence.

  • ≥ 95% Pure CBN Guaranteed
  • ≤ 0.01% THC
  • Made in the USA – American Grown and Processed Industrial Hemp
  • Fragrance – Sharp, earthy aroma
  • Taste – Little to none
  • Color – Fine white crystalline fluffy powder
  • Shelf Life – 1 Year
The Made in the USA badge communicates that all of Red Mesa Science and Refining CBD Isolates and Distillates, CBG Iso;atesa nd Distillates, CBN Isolates and Distillates are made in the USA
THe FDA Registered Food Facility badge communicates that Red Mesa Science & Refining is an FDA Registered Food Facility
cGMP Badge demonstrates that Red Mesa Science & Refining is following current good manufacturing practices to provide high quality products with complete transparency
ISO 17025 badge demonstrates that Red Mesa Science and Refining uses an ISO 17025 accredited third party lab for COAs to communicate trust in the quality and potency of our cannabinoids.
ISO 9001:2015 certification badge demonstrates Red Mesa Science & Refining operates to the highest quality standards and is continuously improving upon procedures and methods for increased customer satisfaction.
Badge for GMP Compliant Human Food to demonstrate Red mesa Science & Refining adheres to 21 CFR 117 regulations
The GMP Compliant 21 CFR 111 badge represents Compliant Dietary Supplement processes and demonstrates Red Mesa Science & Refining adheres to 21 CFR 111 regulations
100% guarantee of satisfactions badge communicates our guarantee to customers who purchase our CBD, CBG, CBN cannabinoid raw ingredients.
The Non-GMO badge demonstrate that Red Mesa Science & Refining cbd, cbg, cbn cannabinoid raw ingredients are non-gmo
Vegan badge demostrates that Red Mesa Science & Refining's cbd, cbg, cbn cannabinoid raw ingredients are vegan.

It’s About Trust

Our ISO 17025 accredited third-party lab tests every batch for cannabinoid profile, residual solvents, pesticides, heavy metals, microbial counts and mycotoxins per R68-37 assuring our products meet our quality standards as well as current federal and state regulations (read more).

The Promises We Speak Of Are The Results We Deliver.

The downloadable CBN Isolate Product Specifications Sheet provides guaranteed minimum cannabinoid concentration levels and product characteristics you can count on with each order placed.

For your convenience, we have provided a CBN Isolate Sell Sheet available for download to keep for yourself or share with others. 

Thoughtful Packaging Secures Contents and Promotes Longevity

Our CBN Isolate is packaged in either food-grade bags or food-grade HDPE containers. Our stand-up EU & US FDA compliant polyethylene bags hold up to 10 kgs with tear notch and re-closable zipper for easy dispensing and disposal with less environmental waste. The HDPE container preserves freshness and shelf life by reducing light exposure and to help maintain temperature control. The screw-top lid keeps out excess oxygen and other potential contaminants as well as being tamper resistant. Our packaging comes with a label listing the Lot ID number, manufactured date and a QR code to access ISO 17025 accredited third-party CoA reports quickly.

The Science Behind Formulating Products with CBN Isolate


CBN is considered a minor compound resulting from the decomposition and oxidation of THC. Industrial hemp, by law, cannot exceed 0.3% THC; therefore, only trace amounts are recovered when hemp-derived CBN is extracted naturally. Understanding the promising benefits of CBN, our scientists and chemists have developed a method to convert other carboxylic acid forms of cannabinoids into CBN to produce an ultra-pure, THC-Free, bulk CBN Isolate powder to meet growing demand. 

Assuring CBN Isolate Quality

Processed in our FDA Food Registered, cGMP adherent, ISO 9001:2015 certified facility, our CBN Isolate is manufactured adhering to both dietary supplements (21 CFR Part 111) as well as food and beverage (21 CFR Part 117) regulations to ensure quality, potency and purity. Additionally, our in-house lab provides proximity to the production floor to allow for routine analytical testing throughout manufacturing to evaluate consistency, production controls and optimization of processes. 

Learn More About CBN Isolate

With the increasing popularity of cannabinoid-based products, there is a growing demand for innovative formulations that capitalize upon the potential benefits of CBN isolate. While research is still in its infancy compared to CBD, CBG and THC, CBN has exhibited promising potential in enhancing relaxation and sleep quality (see study), anti-inflammation support (see study), neuroprotective effects against oxytosis/ferroptosis (see study), among other potential benefits.

Cannabinoid Research and Potential Benefits

Curious about the potential benefits of other cannabinoids? Read our Research Briefs and Articles summarizing cannabinoid research and studies, with cited sources and links to the in-depth research and studies.

Frequently Asked Questions about CBN Isolate Powder

CBN Isolate or Cannabinol Isolate is highly refined to be 95% or greater in CBN purity resulting in a powdered form of nearly pure CBN. In nature, CBN is formed when THC oxidizes and decomposes, typically through exposure to air or heat. However, because Industrial Hemp extract is ≤ 0.3% THC, the opportunity to produce hemp-derived CBN through oxidation is minimal. Fortunately, scientists and chemists have developed methods in the laboratory to produce CBN Isolate from other cannabinoids, so the powder form of bulk CBN Isolate is available to meet rising demand.

CBN interacts with the body’s endocannabinoid system by binding primarily to the CB2 receptor with minor interactions with the CB1 receptors. Within the endocannabinoid system, the CB2 receptor is associated with the immune system showing that it may modulate immune cell functions


Promising preliminary research has indicated that CBN may have potential therapeutic benefits in promoting sleep with additional anti-inflammatory and immunosuppressive properties with continued interest in CBNs potential to trigger apoptosis (cell death) to inhibit tumor cell growth in some cancers.

CBN, or pure Cannabinol, is a cannabinoid found in cannabis sativa plants. While CBN is often associated with sedation and relaxation, it is generally considered non-psychoactive compared to other cannabinoids like THC (tetrahydrocannabinol).

CBN Isolate is not a form of THC, although CBN can be converted from the oxidation of THC. However, to fulfill mass production needs, hemp-derived CBN bulk quantities can also be manufactured more efficiently using base materials CBD and CBG to produce THC-free high-purity CBN Isolate.

 Both CBN (Cannabinol) and CBD (cannabidiol) are cannabinoids found in the cannabis plant, but with some key differences:

Chemical Structure – CBN and CBD have different chemical structures. CBN is a minor cannabinoid naturally derived from THC through oxidation and decomposition unless converted in a laboratory using other cannabinoids as a base. CBD, in comparison, is a major cannabinoid, being one of two predominant cannabinoids, occurring naturally present within the plant without being a degradation product.


Psychoactive Effects Both CBN and CBD are non-intoxicating cannabinoids. CBN is generally considered to have mild sedative properties, which may contribute to its potential calming and relaxing effects. It is often associated with promoting sleep and has been reported to have a more sedative effect than CBD. On the other hand, CBD is considered non-intoxicating and is often associated with potential anti-anxiety and anti-inflammatory effects.


Potential Benefits – Although having some similar properties due to their structural similarities, CBN and CBD have different effects on the endocannabinoid system and interact with different cannabinoid receptors. 


Of the two, CBD has been more extensively studied and is associated with potential therapeutic benefits, including pain relief, reducing anxiety, aiding in sleep and potentially addressing certain seizure disorders. Having been less studied, CBN is believed to have potential benefits for sleep promotion, anti-inflammatory, analgesic (pain-relieving), antibacterial effects and appetite stimulation. While CBN and CBD have shown promise in various areas, research is ongoing to understand their effects fully.


Availability and Regulation– Regulations regarding CBN and CBD can vary between countries and regions, with accessibility being readily available or limited according to jurisdictions. CBD has gained wider acceptance and is more available in many parts of the world. It is used in various products such as oils, capsules, topicals, and edibles. On the other hand, CBN is less common and may be found in specific products targeting sleep or relaxation.

 CBN (Cannabinol) and CBG (Cannabigerol) are two different compounds found in the cannabis sativa plant, alongside the more well-known cannabinoids THC and CBD (cannabidiol). 


CBN is a cannabinoid that is formed naturally from the degradation of THC. When THC is exposed to oxygen and light, it degrades gradually to form CBN. Due to the rare occurrence of CBN within the hemp plant, scientists and chemists have developed methods to convert base cannabinoids such as CBDa and CBGa into CBN. CBN is often associated with promoting relaxation and aiding sleep. Some research suggests that CBN may have potential therapeutic effects, such as pain relief and anti-inflammatory properties, but further studies are needed to understand its potential benefits fully.


CBG is considered a minor cannabinoid because of its low concentration in most cannabis strains. However, genetics has produced a CBG-rich hemp strain that makes it possible to extract CBG in high concentrations. CBG is known as the “mother of all cannabinoids” as it plays a crucial role as the precursor molecule from which other cannabinoids are synthesized, including THC and CBD has gained attention for its potential therapeutic properties, including anti-inflammatory, analgesic (pain-relieving) and antibacterial effects. Some research also suggests that CBG may have neuroprotective properties, potentially beneficial for certain neurological conditions.

CBN (Cannabinol) is one of many cannabinoids in the cannabis plant. The legality of CBN depends on the specific jurisdiction and the source from which it is derived. In many countries, including the United States, the legal status of cannabinoids is primarily determined by whether they are derived from marijuana or hemp. CBN derived from hemp is generally legal in the United States as long as it contains levels below the legal limit of 0.3% THC. 


As with any cannabis-derived product, checking the legality of CBN in your jurisdiction is essential, as cannabis laws can vary from place to place. 

Red Mesa sells to product formulators, co-packers, distributors and other B2B customers. Wholesale CBN Isolate can be purchased directly from our website or quoted at bulk CBN Isolate wholesale pricing for larger quantities. 

If you have any additional questions or require further assistance, please contact our sales support team. We’re here to help you make informed decisions to provide your customers with the highest quality CBD, CBG, CBN and other minor cannabinoid raw ingredients to grow brand loyalty and help protect your brand reputation.

We offer CBN Isolate in various quantities, from small quantities for R&D and small-scale formulation needs starting at 25 grams to larger volumes for commercial manufacturing in the hundreds of kgs. Our flexible ordering options allow you to choose the most appropriate volume for your requirements.

Yes, the third-party lab we send our batch-specific CBN Isolate samples to has been inspected and has demonstrated operational competency with the ability to generate valid testing results to earn the ISO 17025 accreditation. This level of accreditation is vital for Red Mesa Science & Refining to extend confidence in the quality of our products to our customers. (read more)

Red Mesa Science & Refining has received and has maintained a comprehensive end-to-end ISO 9001:2015 certification. (read more)

Red Mesa Science & Refining is registered as a food facility with the FDA and subject to random inspections. (read more)

Yes, as a hemp processor in the state of Utah, we are required to adhere to cGMP requirements for dietary supplements and human food. (read more)

As a science-based, innovative company we collaborate with our customers providing valuable insight into helping choose the ideal cannabinoid characteristics, purity levels, blends etc. for their end product formulations. Please contact us to discuss your specific formulating needs.

Why Choose Red Mesa Science & Refining for Your Bulk Cannabinoid Raw Ingredients?

Prioritizing Quality Assurance – Quality is Central to Manufacturing CBD Isolate

Quality Assurance is at the heart of our production process. We prioritize quality by operating under stringent guidelines to ensure our customers receive products that abide by regulations and meet or exceed industry standards.

Quality and  Regulatory Compliance at the Forefront

  • Strict Quality Management System – Under the guidance of ISO 9001:2015 certification and cGMP, our production processes are focused intently on optimal quality and safety.
  • Higher Standards – Red Mesa is uniquely held accountable to adhere to both 21 CFR Part 111 (dietary supplements) and 21 CFR Part 117 (food and beverage) standards, furthering our commitment to ensuring our CBD Isolate is of the highest quality.
  • Internal Testing Protocols – We thoroughly examine, test and analyze the CBD Isolate material through to completion. Our team of onsite scientists and chemists perform routine analytical tests throughout production to uphold our promise to guarantee the consistent delivery of products to guaranteed specifications. 
  • ISO 17025 Accredited Trustworthy and Reliable COAs – Upon completion of manufacturing, final batch-specific testing is administered by an independent ISO 17025 accredited third-party laboratory. The resulting COAs provide added confidence in verifying cannabinoid potency and compliance regarding pesticides, residual solvents, heavy metals, mycotoxins and any other undesirable impurities.
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