CBN Isolate
THC-Free CBN Isolate is a purified crystalline cannabinol (CBN ) powder with a guaranteed potency of 98% + CBN. It is manufactured by removing all other cannabinoids, including THC, under stringent quality standards as outlined by our ISO 9001:2015 certification and cGMP conformance. An ISO 17025-accredited third-party lab provides a batch-specific COA for CBN purity and potency, and verifies the federally compliant removal of heavy metals, pesticides, residual solvents, and microbial impurities. While our CBN Isolate is guaranteed to be 0.01% THC or lower, we also offer Japan-compliant CBN Isolate Powder – THC-free Japan, with non-detectable THC at ≤ 10 ppm or 0.001% THC, to meet Japan’s highly restrictive THC limits.
What is CBN Isolate?
Our sulfurless CBN crystalline powder is the purest, most potent and most versatile form of CBN derived from US-grown hemp. Our manufacturing process effectively removes all other cannabinoids, flavonoids, waxes, chlorophyll and terpenes, producing a nearly odorless and tasteless CBN Isolate powder. The resulting oil-soluble, fine, white, highly purified CBN powder provides accurate dosing and facilitates ease in blending into other ingredients.
What is CBN Isolate Used for?
CBN is gaining traction in sectors such as nutraceuticals, cosmetics and wellness products, with its properties having little to no impact on flavor, aroma, or visual profiles.
- Topical – Creams, Lotions, Balms, Salves etc.
- Skincare – Serums, Creams, Masks etc.
- Cosmetics
- Tinctures and Oils
- Capsules and Soft gels
- Edibles – Gummies, Chocolates and Other Confections
From: $130.00
Need a larger quantity? Please contact us for custom wholesale quotes to buy larger bulk quantities or request current batch CoAs.
Delivering What We Promise
Full panel ISO 17025 Accredited Third-Party Lab COAs for added confidence.
- ≥ 98% Pure CBN Guaranteed
- ≤ 0.01% THC
- Made in the USA – American Grown and Processed Industrial Hemp
- Fragrance – Little to none
- Taste – Little to none
- Color – Fine white crystalline fluffy powder
- Shelf Life – 1 Year
- Other – Kosher, Halal, Vegan and Non-GMO
MEMBER
It’s About Trust
Our ISO 17025 accredited third-party lab tests every batch for cannabinoid profile, residual solvents, pesticides, heavy metals, microbial counts and mycotoxins per R68-37, assuring our products meet our quality standards as well as current federal and state regulations (read more).
Manufactured to Product Specifications
The downloadable CBN Isolate Product Specifications Sheet provides guaranteed minimum cannabinoid concentration levels and product characteristics you can count on with each order placed.
Product Features
For your convenience, we have provided a CBN Isolate Sell Sheet available for download to keep for yourself or share with others.
Thoughtful Packaging Secures Contents and Promotes Longevity
Our CBN Isolate is packaged in either food-grade bags or food-grade HDPE containers. Our stand-up EU & US FDA compliant polyethylene bags hold up to 10 kgs with tear notch and re-closable zipper for easy dispensing and disposal with less environmental waste. The HDPE container preserves freshness and shelf life by reducing light exposure and to help maintain temperature control. The screw-top lid keeps out excess oxygen and other potential contaminants as well as being tamper resistant. Our packaging comes with a label listing the Lot ID number, manufactured date and a QR code to access ISO 17025 accredited third-party CoA reports quickly.
What is the Science Behind Manufacturing CBN?
Producing High Purity CBN Powder for Commercial Applications
Cannabinol is considered a minor compound resulting from the decomposition and oxidation of THC. Industrial hemp, by law, cannot exceed 0.3% THC; therefore, only trace amounts are recovered when hemp-derived CBN is extracted naturally. Understanding the promising benefits of CBN, our scientists and chemists have developed a method to convert other carboxylic acid forms of cannabinoids into CBN to produce an ultra-pure, THC-Free, bulk CBN Isolate powder to meet growing demand. The process is complex, utilizing customized equipment throughout nearly every stage of operation. Learn more about the equipment used to refine and purify CBN Isolate.
Assuring CBN Isolate Quality
Processed in our FDA Food Registered, cGMP adherent, ISO 9001:2015 certified facility, our CBN Isolate is manufactured adhering to both dietary supplements (21 CFR Part 111) as well as food and beverage (21 CFR Part 117) regulations to ensure quality, potency and purity. Additionally, our in-house lab provides proximity to the production floor to allow for routine analytical testing throughout manufacturing to evaluate consistency, production controls and optimization of processes.
Learn More About CBN Isolate
Why Do Manufacturers Choose Cannabinol Isolate?
Manufacturers choose CBN Isolate for:
- THC-free formulations
- Precise dosing
- Neutral flavor and appearance
- Consistency across production batches
What Form of CBN is Most Effective?
Selecting the most effective CBN form for your product depends entirely on your formulation goals. Whether you choose CBN Isolate, CBN Distillate, CBN Crystal Resistant Distillate or Water Soluble CBN, the decision often hinges on factors like desired potency or the inclusion of other cannabinoids to enhance the Entourage Effect. Learn more about the unique characteristics of each CBN format by exploring this article.
CBN Cannabinoid Research
With the increasing popularity of cannabinoid-based products, there is a growing demand for innovative formulations that capitalize on the potential benefits of high purity CBN. While research is still in its infancy compared to CBD, CBG and THC, CBN has exhibited promising potential in enhancing relaxation and sleep quality (see study), anti-inflammation support (see study), neuroprotective effects against oxytosis/ferroptosis (see study), among other potential benefits.
| CBN RESEARCH KEY FINDINGS | RESEARCH/STUDY LINK |
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Sleep Aid – 20 mg CBN reduced awakenings and sleep disturbance vs placebo. |
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Pain Relief / Anti-Inflammatory – CBN demonstrated Pain RElief and Anti-inflammatory properties Reduced mechanical hypersensitivity and inflammation; no motor impairment.outperforming CBD. |
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Neuroprotective Potential – Improved cognition, mitochondrial function, and synaptic plasticity. |
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Antibacterial / Antibiofilm – Potent MRSA biofilm inhibition and bacterial killing. |
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Glaucoma Management / IOP Reduction – Lowered intraocular pressure and protected retinal ganglion cells. |
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Anticonvulsant Properties – Reduced seizure-like activity at low doses without heavy sedation. |
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Other Cannabinoid Research and Potential Benefits
Curious about the potential benefits of other cannabinoids? Read our Research Briefs and Articles summarizing cannabinoid research and studies, with cited sources and links to the in-depth research and studies.
Frequently Asked Questions about CBN Isolate Powder
What is Cannabinol Isolate?
Cannabinol Isolate or CBN isolate is a purified form of cannabinol (CBN) that contains ≥98% CBN by weight. It is produced by removing all other cannabinoids, terpenes, flavonoids, waxes, and plant material from hemp extract, resulting in a white, odorless crystalline powder.
In nature, CBN is formed when THC oxidizes and decomposes, typically through exposure to air or heat. However, because Industrial Hemp extract is ≤ 0.3% THC, the opportunity to produce hemp-derived CBN through oxidation is minimal. Fortunately, scientists and chemists have developed methods in the laboratory to produce CBN Isolate from other cannabinoids, so the powder form of bulk CBN Isolate is available to meet rising demand.
What Does CBN Isolate Look Like?
CBN Isolate appears as a fine, white or off-white crystalline powder with little to no taste or odor, making it ideal for products requiring flavor neutrality and visual clarity.
How pure is CBN Isolate?
High-quality CBN Isolate typically tests at 97% – 99% CBN. Testing by third-party labs will provide Certificates of Analysis (COAs) to confirm potency and contaminant analysis.
How does CBN interact with the body?
CBN interacts with the body’s endocannabinoid system by binding primarily to the CB2 receptor with minor interactions with the CB1 receptors. Within the endocannabinoid system, the CB2 receptor is associated with the immune system showing that it may modulate immune cell functions.
Promising preliminary research has indicated that CBN may have potential therapeutic benefits in promoting sleep with additional anti-inflammatory and immunosuppressive properties with continued interest in CBNs potential to trigger apoptosis (cell death) to inhibit tumor cell growth in some cancers.
Is CBN Isolate Psychoactive?
Is CBN Isolate THC-Free
Yes, CBN Isolate is inherently THC-Free when properly manufactured and verified by testing. Reputable manufacturers will provide third-party Certificates of Analysis (COAs) confirming non-detect delta 9 THC, typically below 0.01%
In nature, CBN Isolate is not a form of THC, although CBN can be converted from the oxidation of THC. However, to fulfill mass production needs, hemp-derived CBN bulk quantities can also be manufactured more efficiently using base materials CBD and CBG to convert into THC-free high-purity CBN Isolate.
Is CBN Legal?
Does CBN Isolate dissolve in water?
CBN Isolate is not water-soluble in its natural form. It is fat-soluble and dissolves well in oils. Choose Water Soluble CBN Isolate that has been nanoemulsified if. your product formulation is water-based formulations, like beverages, serums, gummies etc.,
What are the common CBN Isolate product applications?
CBN isolate is commonly used in:
- Dietary supplements and capsules
- Tinctures
- Cosmetics, skincare and topicals
- Functional foods
- Nutraceutical and R&D applications
CBN Isolate’s consistency and purity make it preferred for precise dosing and compliant formulations.
What's the difference between CBD and CBN?
Both CBN (Cannabinol) and CBD (cannabidiol) are cannabinoids found in the cannabis plant, but with some key differences:
Chemical Structure – CBN and CBD have different chemical structures. CBN is a minor cannabinoid naturally derived from THC through oxidation and decomposition unless converted in a laboratory using other cannabinoids as a base. CBD, in comparison, is a major cannabinoid, being one of two predominant cannabinoids, occurring naturally present within the plant without being a degradation product.
Psychoactive Effects – Both CBN and CBD are non-intoxicating cannabinoids. CBN is generally considered to have mild sedative properties, which may contribute to its potential calming and relaxing effects. It is often associated with promoting sleep and has been reported to have a more sedative effect than CBD. On the other hand, CBD is considered non-intoxicating and is often associated with potential anti-anxiety and anti-inflammatory effects.
Potential Benefits – Although having some similar properties due to their structural similarities, CBN and CBD have different effects on the endocannabinoid system and interact with different cannabinoid receptors.
Of the two, CBD has been more extensively studied and is associated with potential therapeutic benefits, including pain relief, reducing anxiety, aiding in sleep and potentially addressing certain seizure disorders. Having been less studied, CBN is believed to have potential benefits for sleep promotion, anti-inflammatory, analgesic (pain-relieving), antibacterial effects and appetite stimulation. While CBN and CBD have shown promise in various areas, research is ongoing to understand their effects fully.
Availability and Regulation– Regulations regarding CBN and CBD can vary between countries and regions, with accessibility being readily available or limited according to jurisdictions. CBD has gained wider acceptance and is more available in many parts of the world. It is used in various products such as oils, capsules, topicals, and edibles. On the other hand, CBN is less common and may be found in specific products targeting sleep or relaxation.
CBN vs CBG
CBN (Cannabinol) and CBG (Cannabigerol) are two different compounds found in the cannabis sativa plant, alongside the more well-known cannabinoids THC and CBD (cannabidiol).
CBN is a cannabinoid that is formed naturally from the degradation of THC. When THC is exposed to oxygen and light, it degrades gradually to form CBN. Due to the rare occurrence of CBN within the hemp plant, scientists and chemists have developed methods to convert base cannabinoids such as CBDa and CBGa into CBN. CBN is often associated with promoting relaxation and aiding sleep. Some research suggests that CBN may have potential therapeutic effects, such as pain relief and anti-inflammatory properties, but further studies are needed to understand its potential benefits fully.
CBG is considered a minor cannabinoid because of its low concentration in most cannabis strains. However, genetics has produced a CBG-rich hemp strain that makes it possible to extract CBG in high concentrations. CBG is known as the “mother of all cannabinoids” as it plays a crucial role as the precursor molecule from which other cannabinoids are synthesized, including THC and CBD has gained attention for its potential therapeutic properties, including anti-inflammatory, analgesic (pain-relieving) and antibacterial effects. Some research also suggests that CBG may have neuroprotective properties, potentially beneficial for certain neurological conditions.
What is the Difference Between CBN Isolate and Full Spectrum?
- CBN Isolate: Contains only Cannabinol, and zero THC or other cannabinoids.
- Full Spectrum: Contains CBN, CBD and other minor cannabinoids and trace THC (≤ 0.3% in the US).
CBN Isolate is the ideal choice for the avoidance of THC, to support regulatory clarity and export compliance.
How is CBN Isolate stored?
CBN Isolate Powder should be stored in airtight, food-grade containers away from direct light, below 77º F (25º C) and away from humidity.
What cerifications should CBN Isolate Suppliers provide?
Important documentations or certificatoin indlus:
- Certificate of analysis (COA)
- CBN potency
- heavy metals, pesticides and residual solvent testing results
- Hemp Source and farm records
- THC compliance
- GMP and ISO certifications
How Do I Buy CBN Isolate at Wholesale?
What are your CBN Isolate MOQs (Minimum order quantities)?
Is your CBN Isolate third-party tested by an ISO 17025 accredited third-party lab?
Is Red Mesa Science & Refining ISO Certified?
Is Red Mesa Science & Refining FDA Registered?
Is Red Mesa Science & Refining complying with cGMP requirements for Dietary supplements and human food?
Do you provide formulation support?
Why Choose Red Mesa Science & Refining for Your Bulk Cannabinoid Raw Ingredients?
Prioritizing Quality Assurance – Quality is Central to Manufacturing CBN Isolate
Quality Assurance is at the heart of our production process. We prioritize quality by operating under stringent guidelines to ensure our customers receive products that abide by regulations and meet or exceed industry standards.
Quality and Regulatory Compliance at the Forefront
- Strict Quality Management System – Under the guidance of and, our production processes are focused on optimal quality and safety.
- Higher Standards – Red Mesa is uniquely held accountable to adhere to both 21 CFR Part 111 (dietary supplements) and 21 CFR Part 117 (food and beverage) standards, furthering our commitment to ensuring our CBN Isolate is of the highest quality.
- Internal Testing Protocols—We thoroughly examine, test and analyze the CBN Isolate material from start to finish. Our team of on-site scientists and chemists performs routine analytical tests throughout production to uphold our promise to guarantee the consistent delivery of products to guaranteed specifications.
- ISO 17025 Accredited Trustworthy and Reliable COAs – Upon completion of manufacturing, final batch-specific testing is administered by an independent ISO 17025 accredited third-party laboratory. The resulting COAs provide added confidence in verifying cannabinoid potency and compliance regarding pesticides, residual solvents, heavy metals, mycotoxins and any other undesirable impurities.
