CBN 5 Different Ways – CBN Isolates and Distillates

CBN is gaining traction for its unique health and wellness benefits. In. response, Red Mesa Science and Refining is the only processor to offer 5 different CBN Isolates and Distillates, including non-synthetic Botanically Derived CBN Isolate and CBN Distillate. The full line of CBN raw materials includes CBN Isolate, CBN Distillate, CBN Crystal Resistant Distillate, CBN Isolate – Botanical and CBN Distillate - Botanical.

Which CBN Raw Material Should I Use?

Comparing Different Forms of CBN for Effective B2B Formulation

CBN is an emerging cannabinoid gaining traction for its potential therapeutic benefits. As the industry develops, various forms of CBN are available, each with unique physical properties and applications. This blog post will compare five types of bulk CBN Isolates and Distillates produced at industrial scale, most of which are exclusive to Red Mesa Science & Refining: CBN Isolate, CBN Distillate, CBN Crystal Resistant Distillate – High Minors, CBN Isolate – Botanical and CBN Distillate – Botanical. We’ll explore their differences, formulation advantages and consumer product applications to help businesses make informed decisions.

What is CBN?

Cannabinol (CBN) is naturally found in Cannabis sativa formed when THC oxidizes and decomposes, typically through exposure to air or heat. However, by law, when Industrial Hemp is harvested, it can’t be ≤ 0.3% THC, decreasing the opportunity to produce hemp-derived CBN through oxidation naturally. Fortunately, scientists and chemists have developed methods to ensure CBN is available to meet rising demand. Unlike THC, CBN is generally considered non-intoxicating and is often associated with potential benefits such as improved sleep (read more), pain relief and anti-inflammatory properties. As research continues, the demand for CBN-based products in both B2B and B2C markets is increasing.

Types of CBN Isolates and Distillates - What are the Difference?

Product Demos

View CBN Isolate and Distillate product demonstrations and explore the differences in physical characteristics and guaranteed product specifications.

CBN Isolate

CBN isolate is the purest form of CBN, containing ≥ 95% CBN. It is refined and purified in a CBN crystalline powder form, making it easy to work with during product formulation. Read More 


  • Purity: High purity ensures consistent dosing without interference from other cannabinoids or terpenes.
  • Versatility: Suitable for various formulations targeting CBN’s unique benefits, such as edibles, tinctures, capsules and topicals.
  • Stability: Resistant to degradation when stored properly.


  • Edibles: Easily integrated into gummies, chocolates and other confectionaries.
  • Topicals: Ideal for creams, balms and lotions.
  • Tinctures and Capsules: Provides precise dosing, essential for oral consumption products.

CBN Distillate

CBN Distillate is a refined form of CBN that contains a high percentage of CBN (≥ 85%).  It has a viscous, oil-like consistency when heated. Read More 


  • Flexibility: Can be tailored to CBN’s unique therapeutic properties or easily blended with other cannabinoids to create a synergistic blend.
  • Stability: Resistant to degradation when stored properly.


  • Topicals: Creams, balms and lotions
  • Edibles: Adds complexity to flavor profiles in gourmet edible products.
  • Tinctures and Capsules

CBN Crystal Resistant Distillate – High Minors

CBN Crystal Resistant Distillate – High Minors is refined and purified to resist crystallization, maintaining its viscous state throughout its shelf life. Its additional ≥ 25% in Minors (CBD, CBG, CBT and others), combined with the high concentration of CBN, can contribute to the Entourage Effect, where the cannabinoids work together to make each more effective. This form of CBN is ideal for applications where stability and consistency are critical. Read More 


  • Stability: Non-crystallizing to ensure a uniform product over time without using diluents or cutting agents.
  • Ease of Use: Its non-crystallizing characteristic simplifies manufacturing by eliminating the need for frequent reheating or remixing.


  • Vape Products: Maintains fluidity even at lower temperatures, enhancing user experience.
  • Tinctures: Ensures a smooth, consistent pour without crystal formation.
  • Topicals: Prevents graininess in cosmetics, skincare, creams and lotions, providing a smooth texture.

CBN Isolate- Botanical

CBN Isolate—Botanical is produced using a highly sophisticated chromatographic separation technology to separate CBN and other cannabinoids without using chemical catalyst conversion methods. Read More


  • Non-Synthetic Source: Appeals to markets seeking naturally refined and purified CBN with regulatory restrictions on synthetic cannabinoids.
  • High Purity: Maintains similar purity levels to traditional CBN Isolate.
  • Stability: Resistant to degradation when stored properly.


  • Nutraceuticals: Suitable for supplements in regions with strict cannabis regulations.
  • Cosmetics: Ideal for beauty products requiring natural alternatives.
  • Functional Foods: Integrates seamlessly into health-focused food products.

CBN Distillate – Botanical

CBN Distillate – Botanical offers a naturally refined and processed CBN broad-spectrum distillate with high minors sourced from industrial hemp. This option provides the benefits of distillate without the association with synthetic CBN. Read More


  • Regulatory Compliance: Has met the demands of markets with stringent synthetic cannabinoid restrictions.
  • Synergistic Effects: Broad-spectrum formulation harnesses the benefits of multiple cannabinoid compounds working together to increase the effectiveness of each.
  • Stability: Resistant to degradation when stored properly.


  • Wellness Products: Fits well into holistic health products emphasizing plant-based ingredients.
  • Topicals: Offers a natural option for cosmetic and skincare products promoting plant-derived benefits.

Comparing Formulation Benefits

When selecting the right form of CBN for product formulation, several factors must be considered:

Consistency and Purity

  • Best Option: CBN Isolate and CBN Isolate – Botanical are superior for applications requiring high purity and precision, such as pharmaceuticals and nutraceuticals.


  • Best Option: CBN Crystal Resistant Distillate – High Minors excels in formulations needing long-term stability, such as tinctures and vape products without adding diluents or cutting agents.

Entourage Effect

  • Best Option: CBN Crystal Resistant Distillate – High Minors and CBN Distillate – Botanical leverage the entourage effect, making them ideal for therapeutic products seeking enhanced efficacy through the synergy of cannabinoids.

Consumer Product Applications


  • Ideal Form: CBN Isolate and CBN Isolate – Botanical
  • Reason: The purity and neutral taste ensure no off-flavors, offering a clean integration into food and drink.


  • Ideal Form: CBN Distillate, CBN Distillate – Botanical and CBN Crystal Resistant Distillate
  • Reason: Easily integrate into oil-based formulations. CBN Distillate fosters targeted CBN health and wellness beneftis while CBN Distillate – Botanical and CBN Crystal Resistant Distillate features broad-spectrum benefits enhancing the therapeutic potential.

Vape Products

  • Ideal Form: CBN Crystal Resistant Distillate
  • Reason: The viscosity and resistance to crystallization are crucial for maintaining quality and user experience.

Tinctures and Capsules

  • Ideal Form: CBN Isolate and CBN Isolate – Botanical
  • Reason: These forms offer precise dosing, essential for products aiming for accurate and consistent dosage.

In Conclusion

Choosing the right type of CBN depends on the specific needs of your formulation and the desired consumer product application. CBN Isolate and CBN Isolate – Botanical are best for high-purity applications. CBN Distillate, CBN Crystal Resistant Distillate – High Minors and CBN Distillate – Botanical are ideal for oil-based formulations requiring liquid to integrate. CBN Crystal Resistant Distillate is the optimal choice for products requiring stability and resistance to crystallization. By understanding the unique properties and benefits of each form of CBN, businesses and brands can create innovative, effective and compliant products that meet market demands.

Contact Our Team of Experts 

Understanding the nuances between different forms of CBN is crucial for companies looking to incorporate Cannabinol into their product lines. 

Contact our experts today to learn more about how each type of CBN can be leveraged in your formulations, ensuring you deliver high-quality, effective products to your consumers.

By comparing these five types of CBN and their applications, we provide businesses with the knowledge needed to make informed decisions, fostering innovation and growth within the cannabinoid product market.


Red Mesa Science & Refining exceeds industry regulatory standards to deliver the highest-quality cannabinoid raw materials. Read our blog post “Excellence Uncompromised” to learn about our diligence in ensuring customer trust and satisfaction with every order. Final batch-specific ISO 17025 third-party accredited COAs accompany each order and are available upon request. Please contact us so we can explain firsthand why we can be a trusted partner in your supply chain. 

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