Fulfilling Consumer-Led Demand for Naturally Produced Minor Cannabinoids
The low concentration of rare minor cannabinoids within the hemp plant has historically made their commercial-scale production challenging. Traditionally, chemical conversion from other cannabinoids has been the primary method for producing these minor cannabinoids. However, Red Mesa Science & Refining has developed a proprietary process that overcomes these challenges without using acids or chemical conversions.
Red Mesa’s revolutionary botanical refinement process represents a significant shift from the industry’s traditional reliance on chemical catalyst conversions to produce rare cannabinoids at scalable production. Arising out of this breakthrough in the manufacturing process, Red Mesa is bringing to market four new non-synthetic products: CBN Isolate – Botanical, CBN Distillate – Botanical, CBT Distillate – Botanical and CBL Isolate – Botanical. While CBN is quickly gaining traction, newcomer cannabinoids CBT and CBL are also rising in desirability yet are currently challenging to source.
What is the Difference Between Chemically Converted Cannabinoids and Botanically Refined Cannabinoids?
Botanically Refined Cannabinoids
Unlike traditional methods that may involve chemical catalyst conversions, our approach ensures that the cannabinoids remain non-synthetic. The process begins with the extraction and distillation of cannabinoids from industrial hemp. The resulting hemp input material is then introduced into our industrial-scale, liquid centrifugal partition chromatography system to fraction out and isolate previously elusive cannabinoids.
This innovative combination of our process with chromatography ensures products come from a botanically refined source, capturing the pure essence of the targeted cannabinoid without chemical conversions.
Botanical refinement’s unique approach offers a significant competitive edge by delivering the compounds’ natural complexity and integrity to the end-user and is increasingly sought after in various industries, including pharmaceuticals, nutraceuticals and cosmetics. Aside from aligning with consumer preferences for naturally derived cannabinoids, these non-synthetic cannabinoids may offer compliant alternatives in states prohibiting synthetic or alternative cannabinoids.
Chemically Converted Cannabinoids
Chemical conversions allow for the production of scarce cannabinoids from more abundant ones, like CBD or THC, making them more accessible and cost-effective. The base cannabinoid is extracted and refined from hemp and then synthesized through chemical processes that alter the structure of the base cannabinoid into the desired cannabinoid.
Although synthetic cannabinoids are produced by way of a chemical transformation, they are chemically similar to the compounds that would be naturally extracted from the hemp plant.

Difficult to Achieve, Until Now – Large-Scale Botanically Refined, Non-Synthetic CBN, CBT and CBL Raw Materials
CBN (Cannabinol)
CBN naturally occurs in the Hemp Cannabis Sativa L plant as THC undergoes oxidation through exposure to air, heat, and light. Given the federally legal limit of 0.3% THC before harvest, very little CBN is produced naturally. Fortunately, scientific advancements have led to more controlled and efficient CBN refinement methods to meet rising demand. Red Mesa offers two botanically refined CBN form factors, CBN Isolate – Botanical and CBN Distillate – Botanical.

CBN Isolate – Botanical
CBN Isolate – Botanical offers exceptional purity, with a guaranteed 95% CBN concentration, ensuring the final product is potent and naturally delivers the intended therapeutic benefits without unwanted impurities and compounds. Its high concentration allows for precise measurement and adjustment to meet specific product specifications, which is crucial for maintaining product consistency. This THC-Free botanically refined Cannabinol Isolate, or CBN Isolate, is refined and purified void of chemical conversions. (learn more)
Why Choose CBN Isolate Botanical?
Our CBN Isolate – Botanical production method is a complex and time-consuming process that employs advanced chromatographic separation methodologies. While this results in lower yields compared to less demanding processes, it is precisely these rigorous methods that make our CBN Isolate – Botanical stand out as a premium CBN Isolate. Being naturally derived, combined with Its rarity and unique production process, offers ample opportunities for product innovation and market differentiation.

CBN Distillate – Botanical
Our CBN Distillate – Botanical is refined to ensure a high concentration of CBN, containing 55% or more pure CBN and an additional 10%+ minor cannabinoids such as CBD, CBC, THCV and others. This rare, botanically refined blend can enhance the Entourage Effect, offering a broad spectrum of potential benefits. (learn more)
Why Choose CBN Distillate -Botanical?
Formulators seeking the benefits of broad spectrum cannabinoids may prefer CBN Distillate – Botanical. Its high potency and the presence of other beneficial cannabinoids make it ideal for products designed to leverage the Entourage Effect to potentially enhance therapeutic outcomes.
CBT (Cannabicitran)
CBT is a novel and emerging cannabinoid, gaining significant consumer and scientific interest for its unique properties and potential benefits. Difficult to extract until now, CBT is considered non-psychoactive and offers exciting opportunities for product development. While CBT is structurally similar to the better-known cannabinoids CBD and THC, it possesses its own distinctive molecular structure and unique properties.

CBT Distillate – Botanical
CBT Distillate – Botanical is guaranteed to contain a minimum of 60% pure CBT with additional minors. CBT’s inherent low viscosity naturally prevents crystallization while enhancing fluidity and stability without diluents or cutting agents. This makes CBT ideal for use alone or as a natural anti-crystallization additive in product formulations that require liquidity, such as vape oils and cosmetics.
When blended with other cannabinoids like CBD, CBG or CBN, CBT can thin out the formulation and prevent crystallization. This combination also benefits from the Entourage Effect, where each cannabinoid’s distinct properties synergize to provide a more holistic and comprehensive effect. (learn more)
Why Choose CBT Distillate – Botanical?
Formulators interested in pioneering new cannabinoid-based products might find CBT Distillate – Botanical appealing. CBT can also enhance fluidity and stability in end-product formulations as a natural anti-crystallizing compound.
CBL (Cannabicyclol)
CBL is an exceptionally rare, non-intoxicating and lesser-known cannabinoid that forms within the hemp plant as a result of cannabichromene (CBC) oxidizing into CBL. Our botanical refinement process tackles both its rarity and the growing demand by ensuring the highest concentration of CBL is retained from the hemp plant input material, making it suitable for commercial use. Increasingly, we are seeing formulators looking to innovate with unique cannabinoids such as CBL to differentiate themselves in the market.

CBL Isolate – Botanical
Our botanically derived CBL Isolate – Botanical is THC-Free and guaranteed to be at least 90% pure CBL, which supports greater dosing accuracy and predictability in end-product potency. Its nearly tasteless and odorless properties allow for seamless integration into various formulations, exerting minimal influence on taste or aroma profiles. (learn more)
Why choose CBL Isolate – Botanical?
CBL Isolate – Botanical’s sophisticated manufacturing approach ensures the highest concentration of CBL, consistently delivering uniform purity and potency across batches. Using high potency CBL Isolate – Botanical can help brands stand out by offering products with distinct cannabinoid profiles that appeal to consumers seeking novel experiences.
Who Stands to Benefit from Botanically Refined Minor Cannabinoids?
The B2B landscape, especially product formulators, white labelers and large-scale brands, stands to benefit significantly from the advancement of botanical refinement. From their purity and natural profile to their alignment with market demand for clean-label products, Red Mesa Science & Refining’s range of botanically derived cannabinoid products provides formulators with highly potent, natural cannabinoid profiles to meet diverse formulation needs.
Transformative Innovation Fuels Competitive Advantage
As the industry continues to evolve, staying at the forefront of technological advancements, such as botanical refinement, will be key to maintaining a competitive edge. Our team of chemists and scientists can assist with ingredient selection and consult in product formulation strategies. Contact us today to learn more about how our botanically derived cannabinoids can benefit your formulations.
WE ARE THE MANUFACTURER
As a globally recognized leader, Red Mesa prioritizes the reliability and consistent production of the highest quality CBD, CBG and CBN isolates, distillates, crystal resistant distillates and CBN, CBT and CBL botanically refined isolates and distillates. We place a high value on innovation and research to remain cutting edge to pass on our competitive advantage to our customers.
We are ISO 9001:2015 certified, cGMP adherent and operate to the FDA 21 CFR Parts 111 & 117 (dietary supplements and food & beverage). Red Mesa prioritizes the reliability and consistent production of the highest quality CBD, CBG and CBN isolates, distillates, crystal resistant distillates and CBN, CBT and CBL botanically refined isolates and distillates with ISO 17025 third-party lab-accredited COAs. Read our blog post “Excellence Uncompromised” to learn about our diligence in ensuring customer trust and satisfaction with every order.