THCV Isolate
THCV Delta-9-tetrahydrocannabivarin is a rare and unique minor cannabinoid that is gaining significant traction in the wellness, weight management and energy-focused markets. Unlike THC, THCV is generally considered non-intoxicating and is being studied for its pharmacological properties, including appetite suppression, enhanced focus and improved metabolic support, all of which have attracted significant commercial interest.
What Makes THCV Unique?
Δ9-THCV’s molecular structure, a three-carbon side chain instead of THC’s five-carbon chain, gives it distinct therapeutic properties, making it a high-value THC-free ingredient for innovative formulation. Early research highlights its value in promoting mental clarity, supporting energy and fostering better focus. Additionally, THCV is being studied for its potential roles in appetite suppression and metabolic support, presenting a significant expansion opportunity into the weight management market.
PLEASE NOTE: We only ship THCV Isolate Monday – Thursday to prevent overheating in transit. Special arrangements can be made for Saturday deliveries, but must be prearranged by contacting us.
Buy THCV Isolate wholesale at low minimum order quantities (MOQs) or in Kilogram quantities
From: $650.00
Need a larger quantity? Please contact us for custom wholesale quotes to buy larger bulk quantities or request current batch CoAs.
Delivering What We Promise
Full panel ISO 17025 Accredited Third-Party Lab COAs for added confidence.
- ≥ 95% Pure THCV
- ≤ 0.05% THC
- Made in the USA
- Color – Hard deep yellow to purple (when exposed to oxygen) resin
- Other – Vegan and Non-GMO
It’s About Trust
A reputable Third-party lab tests and provides batch-specific COAs confirming cannabinoid profile as well as the removal of residual solvents, pesticides, heavy metals, microbial counts and mycotoxins per R68-37, assuring products meet internal quality standards as well as current federal and state regulations.
Due to its unique chemical properties, THCV requires specific handling protocols to preserve its stability,
potency and appearance.
THCV will be shipped in an opaque Nalgene airtight container purged with an inert gas. Refrigerate or freeze upon receipt and avoid opening the container until ready for use.
• Control the environment by using opaque containers and maintaining cool storage temperatures, avoiding temperatures above 65°C.
• Use inert gas purging during packaging, resealing and storage to limit exposure ot oxygen.
• Gently crush THCV; do not grind or scrape THCV with any tools as this will increase the surface area, prompting further oxidation and color change.
• Incorporate promptly into the formulation to prevent degradation before the final product is manufactured.
Note: THCV will react to oxygen exposure by turning purple on the surface. However, if protected from air and higher temperatures, it will remain a yellowish-amber color with a sticky, hard consistency. Stored correctly, once incorporated into a medium such as a carrier oil, or a gummy, vape or tincture, THCV is significantly safeguarded from oxidation with little to no impact on your final product’s color.
DOWNLOAD COMPLETE HANDLING AND STORAGE INSTRUCTIONS HERE
The Promises We Speak Of Are The Results We Deliver.
The downloadable THCV Isolate Product Specification Sheet provides guaranteed minimum cannabinoid concentration levels and product characteristics you can count on with each order placed.
For your convenience, we have provided a THCV Isolate Sell Sheet available for download to keep for yourself or share with others.
Learn More About Delta-9 THCV
What is THCV, and how is it manufactured?
The Challenge of Natural THCV Production
Naturally found in trace amounts in certain cannabis plants, the THCV biosynthesis pathway originates from CBGVA and is extremely rare and costly to extract directly from the plant, with the potential of accumulating THC, complicating it further.
Advanced THCV Manufacturing Techniques
To meet growing demand and scalability, years of dedicated research and the expertise of skilled chemists and scientists have led to the development of a highly sophisticated bioidentical manufacturing process, improving accessibility and affordability. The food-grade, cGMP-compliant manufacturing process produces plant-identical Δ9-THCV, replicating the exact molecular structure, to ensure formulation consistency in the production of high-purity THCV end-products. As a proud and trusted Distribution Partner of BayMedica, we offer THC-free Δ9 THCV Isolate, manufactured in accordance with food-grade Current Good Manufacturing Practice (cGMP), helping to ensure quality, safety and compliance with the highest manufacturing standards. Full panel batch-specific third-party lab CoAs will validate regulatory conformance and compliance and are available upon request.
Versatile THCV Product Uses
Hemp-derived, THC-free THCV is ideal on its own or as a synergistic blend with other cannabinoids like CBD, CBG and CBN to enhance efficacy and expand targeted benefits. THCV’s versatility makes it a highly desirable ingredient from gummies to nootropic supplements, appealing to brands expanding across various product categories.
THCV Applications:
- Functional Beverages
- Gummies and Chocolates
- Tinctures
- Capsules, Gelcaps, Soft gels, etc.
- Vapes
- Topicals
What Studies Support THCV’s Health and Wellness Benefits?
THCV has been studied and found to influence physiological functions within the body’s endocannabinoid system as an agonist of CB2, TRPV1, TRPA1 and GPR55, while also acting as an antagonist of CB1, TRPV5, TRPV6 and inhibits 2-AG.
THCV Interactions with the Endocannabinoid System
Having been well-studied, D9 THCV has been the focus of research and various studies
- Boosting energy levels and aiding in weight reduction, making it a promising candidate for obesity treatment.
- Potential therapeutic benefit for the management of obesity and diabetes
- Insulin sensitivity in two mouse models of obesity
- Weight Loss and Therapeutic Metabolic Effects of Tetrahydrocannabivarin (THCV)
- “Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers.”
- Improving glycemic control by reducing blood glucose levels.
Contact us to receive the D9 THCV White Paper.
Frequently Asked Questions about THCV
Is the sharp rise in demand for THCV Consumer demand or just hype?
According to Headset retail sales data, THCV edibles (primarily gummies) are experiencing explosive growth driven by consumer demand and are projected to hit $63M by the end of 2025 as more brands enter the market, with significant opportunities to expand into the vape and beverage markets. In 2024, THCV edibles commanded a 23.7% retail price premium, with positioning directed towards energy-boosting, focus-enhancing and appetite-regulating.
What studies support THCV for weight loss and increased energy?
As a CB1 receptor antagonist and CB2 partial agonist within the body’s endocannabinoid system, THCV may help regulate glucose and energy levels according to studies, offering potential benefits for addressing obesity and type 2 diabetes.
How is THCV Isolate (Tetrahydrocannabivarin) made?
Extracting directly from the cannabis plant traditionally involves methods utilizing ethanol or CO2 extraction to isolate D9 THC from the plant material. With very little occurring naturally, it is a costly and challenging manufacturing method, severely limiting availability and falling well short of demand. Combined with the required removal of THC that naturally exists when extracting directly from the plant, this method lacks economic viability commercially.
Fortunately, extensive research and development efforts have produced a bioidentical manufacturing process that produces our hemp-derived, plant-identical D9 THCV at scale, while meeting the highest standards of quality and consistency to help fulfill demand affordably.
Is THCV an isolate or an oil?
Most isolates are a white crystalline powder, whereas D9 THCV is a yellowish-amber, hard, resinous material when stored refrigerated, frozen, or at room temperature. When heated, it becomes the consistency of oil, which understandably can create confusion. The defining factor is the isolation of one specific cannabinoid, in this case, ≥ 95% D9 THCV, making it a high-purity THCV isolate.
Is your D9 THCV THC-free?
What's difference between D9 THCV and D8 THCV?
D9 THCV is produced naturally in certain strains of the cannabis plant in extremely small quantities or manufactured to be bioidentical. Conversely, D8 THCV is not produced by the plant but rather a byproduct of the degradation of D9 THCV. D9 THCV, either synthesized or plant-derived, is predominantly favored for scientific research examining the effects and potential therapeutic properties of THCV.
Is D9 THCV legal?
The D9 THCV we sell is derived from industrial hemp. The 2018 Farm Bill, which federally legalized hemp, defines Hamp as the following: “the plant Cannabis sativa L. and any part of that plant, including the seeds thereof and all derivatives, extracts, cannabinoids, isomers, acids, salts and salts of isomers, whether growing or not, with a delta-9 tetrahydrocannabinol [THC] concentration of not more than 0.3 percent on a dry weight basis”. While this is the federal legal stance on hemp, we advise that you check with your jurisdiction’s laws and regulations before purchasing, as they may differ.
THCV vs THC vs CBD: What’s the difference
THCV, THC, and CBD are all cannabinoids, compounds generally found in the cannabis plant. CBD and THC are the most abundant, while THCV is extremely rare in nature and for this reason considered a rare minor cannabinoid. They differ in their chemical structures, effects and potential uses. THC (tetrahydrocannabinol) is best known for its psychoactive effects, or the “high” associated with cannabis. CBD (cannabidiol) does not produce a high and is often used for therapeutic purposes. THCV (tetrahydrocannabivarin) is structurally similar to THC but behaves quite differently in the body and is generally considered non-psychoactive. Each interacts with the endocannabinoid system differently, resulting in unique effects.
- THC binds directly to CB1 receptors in the brain, producing psychoactive effects like euphoria, altered perception and relaxation.
- CBD interacts indirectly with cannabinoid receptors, producing a calming effect without intoxication. CBD products frequently target stress relief, inflammation and sleep support.
- THCV interacts with the CB1 receptor differently. At low doses, it may suppress appetite and provide heightened focus and energy.
How do I prevent a surface-level color shift when THCV is exposed to oxygen?
THCV has a unique surface reaction when exposed to air, which will lead to the surface turning purple. While this is only on the surface, the extent to which it changes color will depend on the particle size. Hence, do not grind or pulverize THCV as this will lead to exponentially increasing the surface area, which will lead to a rapid color transformation and may lead to degradation in potency. It is important to store THCV in an opaque container and a cool, dark environment to support maximum potency and stability.
Under controlled conditions, where THCV is protected from air and properly stored, THCV will remain yellowish-amber in color with a sticky, hard consistency. Once integrated into a medium such as a carrier oil, gummy or vape, THCV is surrounded by the other ingredients, limiting surface exposure to oxygen and additional color changes. Download our detailed storage and handling instructions here.
How should I handle THCV in manufacturing?
Only open the container when ready to add THCV to a product. Measure out what is needed and quickly add to formulations to limit surface exposure to oxygen. Once integrated into a medium such as a carrier oil, gummy vape, etc., THCV is protected from oxidation. We recommend freezing THCV before working with it, breaking it into small shards, to make handling easier. Avoid grinding or pulverizing, as this increases the surface area exposed to air.
If freezing and breaking up is not conducive with your manufacturing process, gently heat THCV to approximately 65° C by placing the container into a water bath. Pour out what is needed directly into the formulation and store the remaining THCV as directed. For complete storage and handling instructions, click here.
How do I store THCV?
When purchasing THCV from Red Mesa, your product will ship with ice packs to help prevent overheating. For this reason, we only ship THCV Monday through Thursday with deliveries on Saturdays upon request (contact sales@redmesascience.com or call 435.677.6363). Upon receipt, we recommend not opening the opaque container and refrigerating or freezing it until ready for use. Integrate THCV into your formulation (do not grind or pulverize material) as soon as possible so it is coated by the other ingredients, minimizing surface oxidative exposure and any additional color changes that may occur when exposed to air. If you are not using the container in its entirety, use nitrogen or argon to purge oxygen and continue to store as suggested. For complete storage and handling instructions, click here.
Is Red Mesa the manufacturer of D9 THCV?
Do you offer volume discounts and bulk THCV for wholesale purchases?
Yes, we offer competitive volume discounts for wholesale THCV purchases. Contact our sales team for more information on our competitive wholesale volume pricing structure.
What is the MOQ (Minimum order quantity) for THCV?
We offer THCV in various quantities, from small quantities of THCV for R&D and small-scale formulation available through the website to larger volumes of THCV for commercial manufacturing in the hundreds of kgs. Our flexible ordering options allow you to choose the most appropriate volume for your requirements.
How can I place an order for bulk THCV?
Why Choose Red Mesa Science & Refining for Your Bulk Cannabinoid Raw Ingredients?
Setting the Standard for Operational Excellence
Since entering the market in 2019, we recognized the industry’s shortcomings and set out to redefine its standards. As a science- and innovation-driven company, our commitment to operational excellence and continuous improvement is unwavering. Our mission to deliver the safest, highest-quality and fully compliant cannabinoid raw ingredients consistently raises the bar for excellence. We are guided daily by the most rigorous Quality Management Systems (QMS), reinforced by certifications, registrations and voluntary compliance:
FDA Registration & cGMP Compliance
Registered under 21 CFR Part 111 (Dietary Supplements) and 21 CFR Part 117 (Human Food), we fully adhere to cGMP standards to guarantee consistent quality and regulatory compliance, as verified through regular internal and third-party audits.
ISO 9001:2015 Certification
Certified ISO 9001:2015, demonstrating our commitment to continuous improvement, customer satisfaction and consistent quality across all operations. This certification verifies that our quality system is structured, effective and aligned with international best practices.
UDAF Compliance & Background Screening
Fully licensed by the Utah Department of Agriculture and Food, we meet all hemp processing regulations, including annual FBI background checks for employees and regular facility inspections and oversight.
Your Success is Our Success
At Red Mesa, customer satisfaction drives everything we do. We specialize in supporting end-product formulators with innovative, scalable and efficient solutions, fostering long-term partnerships. We invite you to see firsthand why Red Mesa is the benchmark for hemp processing excellence.
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